KRAS(G12C) Mutation

KRAS Mutation Diagram

KRAS Mutation Genetic Testing

The KRAS Gene Mutation Analysis Test is a genetic test that detects KRAS gene abnormalities as well as to test and profile KRAS(G12C) antagonists/inhibitors by monitoring GDP or GTP binding status using BODIPY-GDP. It aids in the identification of appropriate therapeutic medications, such as tyrosine kinase inhibitors (TKIs), and disqualifies certain pharmaceuticals from being employed in cancer treatment.

For additional flexibility, the kit can be used with one of two protocols: titrating the inhibitor with a set GTP concentration or titrating the GTP with a fixed inhibitor concentration.

Specifications

Description: KRAS proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:6407]

Gene Synonyms: KRAS1, KRAS2

Location: Chromosome 12: 25,205,246-25,250,936 reverse strand. GRCh38:CM000674.2

About this gene: This gene has 4 transcripts (splice variants), 200 orthologues, 35 paralogues and is associated with 310 phenotypes.

KRAS table diagram

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