References and Literature

EpigenDx cancer methylation panel

EpigenDx at a Glance

EpigenDx provides epigenetic and genomic services to many academic and corporate institutions. Our high quality research staff and technical support team have worked with many of these customers, helping interpret data and suggesting alternative routes to their research. EpigenDx analyzes thousands of samples annually, across different applications and research goals. Search our database of published journal articles that have referenced EpigenDx’s epigenomic and genomic services.

EpigenDx Presentations

Pyrosequencing is an Effective Method for the Quantitative Analysis of Global and Gene-specific DNA Methylation Using Low Quantities of DNA
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The Use of Pyrosequencing as a Valuable Tool for Detecting Epigenetic and Genetic Alterations in Ovarian Cancer Cell Lines (TT24)
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Pyrosequencing Methylation Profile of Seven Thyroid Cancer Cell Lines (ST07)
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Pyrosequencing Methylation Profile of Five Breast Cancer Cell Lines (ST09)
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References and Literature

A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. Hollenbach PW, Nguyen AN, Brady H, Williams M, Ning Y, Richard N, Krushel L, Aukerman SL, Heise C, MacBeth KJ2010PLoS ONE
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression.Pop R, Shearstone JR, Shen Q, Liu Y, Hallstrom K, Koulnis M, Gribnau J, Socolovsky M2010PLoS Biol.
A prospective study of dietary folate and vitamin B and colon cancer according to microsatellite instability and KRAS mutational status.Schernhammer ES, Giovannuccci E, Fuchs CS, Ogino S2008Cancer Epidemiol. Biomarkers Prev.
A recent adaptive transposable element insertion near highly conserved developmental loci in Drosophila melanogaster.Gonzlez J, Macpherson JM, Petrov DA2009Mol. Biol. Evol.
A subset of methylated CpG sites differentiate psoriatic from normal skin.Roberson ED, Liu Y, Ryan C, Joyce CE, Duan S, Cao L, Martin A, Liao W, Menter A, Bowcock AM2012J. Invest. Dermatol.
A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem CellsEmily Swanzey, Thomas F. McNamara, Effie Apostolou, Mamta Tahiliani, Matthias Stadtfeld2020Cell
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K2010Nature
Age-associated DNA methylation in pediatric populations.Alisch RS, Barwick BG, Chopra P, Myrick LK, Satten GA, Conneely KN, Warren ST2012Genome Res.
Altered DNA methylation in leukocytes with trisomy 21.Kerkel K, Schupf N, Hatta K, Pang D, Salas M, Kratz A, Minden M, Murty V, Zigman WB, Mayeux RP, Jenkins EC, Torkamani A, Schork NJ, Silverman W, Croy BA, Tycko B2010PLoS Genet.
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells.Stadtfeld M, Apostolou E, Ferrari F, Choi J, Walsh RM, Chen T, Ooi SS, Kim SY, Bestor TH, Shioda T, Park PJ, Hochedlinger K2012Nat. Genet.
Assessment of epigenetic contributions to sexually-dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice.Semaan SJ, Dhamija S, Kim J, Ku EC, Kauffman AS2012Endocrinology
Associative DNA methylation changes in children with prenatal alcohol exposure.Laufer BI, Kapalanga J, Castellani CA, Diehl EJ, Yan L, Singh SM 2015Epigenomics
Beyond genotype: serotonin transporter epigenetic modification predicts human brain function.Nikolova YS, Koenen KC, Galea S, Wang CM, Seney ML, Sibille E, Williamson DE, Hariri AR2014Nat. Neurosci.
Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3 Treg cells.Verhagen J, Wraith DC2014J. Immunol. Methods
Brain region-specific expression of Fxyd1, an Mecp2 target gene, is regulated by epigenetic mechanisms.Banine F, Matagne V, Sherman LS, Ojeda SR2011J. Neurosci. Res.
Caloric restriction experience reprograms stress and orexigenic pathways and promotes binge eating.Pankevich DE, Teegarden SL, Hedin AD, Jensen CL, Bale TL2010J. Neurosci.
CGG-repeat dynamics and FMR1 gene silencing in fragile X syndrome stem cells and stem cell-derived neurons.Zhou Y, Kumari D, Sciascia N, Usdin K2016Mol Autism
Chronic stress induces sex-specific alterations in methylation and expression of corticotropin-releasing factor gene in the rat.Sterrenburg L, Gaszner B, Boerrigter J, Santbergen L, Bramini M, Elliott E, Chen A, Peeters BW, Roubos EW, Kozicz T2011PLoS ONE
Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo.Liu J, Ballaney M, Al-alem U, Quan C, Jin X, Perera F, Chen LC, Miller RL2008Toxicol. Sci.
Combining TGF- signal inhibition and connexin43 silencing for iPSC induction from mouse cardiomyocytes.Dai P, Harada Y, Miyachi H, Tanaka H, Kitano S, Adachi T, Suzuki T, Hino H, Takamatsu T2014Sci Rep
Comparison of bisulfite sequencing PCR with pyrosequencing for measuring differences in DNA methylation.Reed K, Poulin ML, Yan L, Parissenti AM 2010Anal. Biochem.
Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatment.Harrington WE, Mutabingwa TK, Muehlenbachs A, Sorensen B, Bolla MC, Fried M, Duffy PE2009Proc. Natl. Acad. Sci. U.S.A.
Correlation of LINE-1 methylation levels in patient-matched buffy coat, serum, buccal cell, and bladder tumor tissue DNA samples.van Bemmel D, Lenz P, Liao LM, Baris D, Sternberg LR, Warner A, Johnson A, Jones M, Kida M, Schwenn M, Schned AR, Silverman DT, Rothman N, Moore LE2012Cancer Epidemiol. Biomarkers Prev.
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer.Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, Loda M, Giovannucci EL, Fuchs CS2009Gut
CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations.Ogino S, Kawasaki T, Kirkner GJ, Loda M, Fuchs CS 2006J Mol Diagn
CpG methylation analysis–current status of clinical assays and potential applications in molecular diagnostics: a report of the Association for Molecular Pathology.Sepulveda AR, Jones D, Ogino S, Samowitz W, Gulley ML, Edwards R, Levenson V, Pratt VM, Yang B, Nafa K, Yan L, Vitazka P 2009J Mol Diagn
Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.Waight JD, Takai S, Marelli B, Qin G, Hance KW, Zhang D, Tighe R, Lan Y, Lo KM, Sabzevari H, Hofmeister R, Wilson NS 2015J. Immunol.
Decitabine reactivated pathways in platinum resistant ovarian cancer.Fang F, Zuo Q, Pilrose J, Wang Y, Shen C, Li M, Wulfridge P, Matei D, Nephew KP 2014Oncotarget
Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice.foxp3Sela U, Olds P, Park A, Schlesinger SJ, Steinman RM 2011J. Exp. Med.
Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls.Sturgeon SR, Balasubramanian R, Schairer C, Muss HB, Ziegler RG, Arcaro KF 2012Epigenetics
Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span.Schwarz JM, Nugent BM, McCarthy MM 2010Endocrinology
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.Urbach A, Bar-Nur O, Daley GQ, Benvenisty N 2010Cell Stem Cell
Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer.bisulfiteClarke MA, Luhn P, Gage JC, Bodelon C, Dunn ST, Walker J, Zuna R, Hewitt S, Killian JK, Yan L, Miller A, Schiffman M, Wentzensen N 2017Int J Cancer
DNA Methylation Analysis: Choosing the Right MethodSergey Kurdyukov, and Martyn Bullock 2016Biology (Basel)
DNA methylation in inflammatory genes among children with obstructive sleep apnea.foxp3Kim J, Bhattacharjee R, Khalyfa A, Kheirandish-Gozal L, Capdevila OS, Wang Y, Gozal D 2012Am. J. Respir. Crit. Care Med.
DNA methylation in multiple myeloma is weakly associated with gene transcription.Jung S, Kim S, Gale M, Cherni I, Fonseca R, Carpten J, Salhia B2012PLoS ONE
DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study.Xu X, Gammon MD, Hernandez-Vargas H, Herceg Z, Wetmur JG, Teitelbaum SL, Bradshaw PT, Neugut AI, Santella RM, Chen J 2012FASEB J.
DNA Methylation of Five Core Circadian Genes Jointly Contributes to Glucose Metabolism: A Gene-Set Analysis in Monozygotic Twins.Hao Peng, Yun Zhu, Jack Goldberg, Viola Vaccarino, and Jinying Zhao 2019Front Genet
DNA methylation pyrosequencing assay is applicable for the assessment of epigenetic active environmental or clinical relevant chemicals.Florea AM 2013Biomed Res Int
Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice.Ganguly S, Ross DB, Panoskaltsis-Mortari A, Kanakry CG, Blazar BR, Levy RB, Luznik L2014Blood
Down-regulation of IL-7Ralpha expression in human T cells via DNA methylation.Kim HR, Hwang KA, Kim KC, Kang I 2007J. Immunol.
DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K2017Cell Stem Cell
Early life stress and voluntary alcohol consumption in relation to Maoa methylation in male rats.Bendre M, Granholm L, Drennan R, Meyer A, Yan L, Nilsson KW, Nylander I, Comasco E 2018Alcohol
Effects of Plasmodium falciparum mixed infections on in vitro antimalarial drug tests and genotyping.Liu S, Mu J, Jiang H, Su XZ2008Am. J. Trop. Med. Hyg.
Elevated levels of DNA methylation at the OPRM1 promoter in blood and sperm from male opioid addicts.Chorbov VM, Todorov AA, Lynskey MT, Cicero TJ2011J Opioid Manag
Endothelial dysfunction in children with obstructive sleep apnea is associated with epigenetic changes in the eNOS gene.Kheirandish-Gozal L, Khalyfa A, Gozal D, Bhattacharjee R, Wang Y2013Chest
Epigenetic and genetic factors predict women’s salivary cortisol following a threat to the social self. Edelman S, Shalev I, Uzefovsky F, Israel S, Knafo A, Kremer I, Mankuta D, Kaitz M, Ebstein RP2012PLoS ONE
Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.Sheridan SD, Theriault KM, Reis SA, Zhou F, Madison JM, Daheron L, Loring JF, Haggarty SJ 2011PLoS ONE
Epigenetic effects of prenatal stress on 11-hydroxysteroid dehydrogenase-2 in the placenta and fetal brain.Jensen Pea C, Monk C, Champagne FA2012PLoS ONE
Epigenetic mechanisms regulate stem cell expressed genes Pou5f1 and Gfra1 in a male germ cell line.Godmann M, May E, Kimmins S2010PLoS ONE
Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. Gornalusse GG, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan MS, Avadhanam N, Murthy KK, Martinez H, Molano Murillo A, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich-Koretskaya L, Abdool Karim S, Martin JN, Deeks SG, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndung’u T, Hunt PW, He W, Ahuja SK2015Proc. Natl. Acad. Sci. U.S.A.
Epigenetic regulation of estrogen receptor alpha gene expression in the mouse cortex during early postnatal development.Westberry JM, Trout AL, Wilson ME2010Endocrinology
Epigenetic targeting of ovarian cancer stem cells.Wang Y, Cardenas H, Fang F, Condello S, Taverna P, Segar M, Liu Y, Nephew KP, Matei D 2014Cancer Res.
Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. Guerrero-Bosagna C, Settles M, Lucker B, Skinner MK2010PLoS ONE
Establishment of Reporter Lines for Detecting Fragile X Mental Retardation (FMR1) Gene Reactivation in Human Neural Cells.Li M, Zhao H, Ananiev GE, Musser MT, Ness KH, Maglaque DL, Saha K, Bhattacharyya A, Zhao X 2017Stem Cells
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation. Rauscher GH, Kresovich JK, Poulin M, Yan L, Macias V, Mahmoud AM, Al-Alem U, Kajdacsy-Balla A, Wiley EL, Tonetti D, Ehrlich M2015BMC Cancer
Family quality of life and ASD: the role of child adaptive functioning and behavior problems.Emily G, Grace I2015Autism Res
Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing.bisulfiteMasser DR, Berg AS, Freeman WM2013Epigenetics Chromatin
Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations.Linhart HG, Troen A, Bell GW, Cantu E, Chao WH, Moran E, Steine E, He T, Jaenisch R 2009Gastroenterology
Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. Iskandar BJ, Rizk E, Meier B, Hariharan N, Bottiglieri T, Finnell RH, Jarrard DF, Banerjee RV, Skene JH, Nelson A, Patel N, Gherasim C, Simon K, Cook TD, Hogan KJ2010J. Clin. Invest.
Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity.Wang L, Liu Y, Beier UH, Han R, Bhatti TR, Akimova T, Hancock WW2013Blood
Generation and characterization of induced pluripotent stem cells from Aid-deficient mice.Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K2014PLoS ONE
Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.Somers A, Jean JC, Sommer CA, Omari A, Ford CC, Mills JA, Ying L, Sommer AG, Jean JM, Smith BW, Lafyatis R, Demierre MF, Weiss DJ, French DL, Gadue P, Murphy GJ, Mostoslavsky G, Kotton DN2010Stem Cells
Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis.Chen Y, Armstrong DA, Salas LA, Hazlett HF, Nymon AB, Dessaint JA, Aridgides DS, Mellinger DL, Liu X, Christensen BC, Ashare A2018Clin Epigenetics
Genomic imprinting of DIO3, a candidate gene for the syndrome associated with human uniparental disomy of chromosome 14.Martinez ME, Cox DF, Youth BP, Hernandez A2016Eur. J. Hum. Genet.
Global DNA demethylation during mouse erythropoiesis in vivo.Shearstone JR, Pop R, Bock C, Boyle P, Meissner A, Socolovsky M2011Science
Helios expression and Foxp3 TSDR methylation of IFNy+ and IFNy- Treg from kidney transplant recipients with good long-term graft function.Trojan K, Unterrainer C, Weimer R, Bulut N, Morath C, Aly M, Zhu L, Opelz G, Daniel V2017PLoS ONE
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ2010Cell Stem Cell
Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.Beier UH, Wang L, Han R, Akimova T, Liu Y, Hancock WW2012Sci Signal
HPA Axis Gene Expression and DNA Methylation Profiles in Rats Exposed to Early Life Stress, Adult Voluntary Ethanol Drinking and Single Housing.Todkar A, Granholm L, Aljumah M, Nilsson KW, Comasco E, Nylander I2015Front Mol Neurosci
Human retinoic acid-regulated CD161+ regulatory T cells support wound repair in intestinal mucosa.foxp3, treg, T cellPovoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen YC, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun HW, Shih HY, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B. 2018Nat Immunol.
Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones.Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, Ho JJ, Gavryushova A, Srivastava D, Marsden PA2010J. Biol. Chem.
Ice-COLD-PCR enables rapid amplification and robust enrichment for low-abundance unknown DNA mutations.Milbury CA, Li J, Makrigiorgos GM2011Nucleic Acids Res.
Identification and analysis of peanut-specific effector T and regulatory T cells in children allergic and tolerant to peanut.foxp3, treg, T cellWeissler KA, Rasooly M, DiMaggio T, Bolan H, Cantave D, Martino D, Neeland MR, Tang MLK, Dang TD, Allen KJ, Frischmeyer-Guerrerio PA2018J. Allergy Clin. Immunol.
IFN+ Treg in-vivo and in-vitro represent both activated nTreg and peripherally induced aTreg and remain phenotypically stable in-vitro after removal of the stimulus.Daniel V, Trojan K, Adamek M, Opelz G 2015BMC Immunol.
IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo.Chen Q, Kim YC, Laurence A, Punkosdy GA, Shevach EM 2011J. Immunol.
Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression.Duclot F, Kabbaj M2013J. Neurosci.
Induced pluripotency of human prostatic epithelial cells.Zhao H, Sun N, Young SR, Nolley R, Santos J, Wu JC, Peehl DM2013PLoS ONE
Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B2014Endocrinology
Insulin gene expression is regulated by DNA methylation.Kuroda A, Rauch TA, Todorov I, Ku HT, Al-Abdullah IH, Kandeel F, Mullen Y, Pfeifer GP, Ferreri K2009PLoS ONE
Insulin Like Growth Factor 2 Expression in the Rat Brain Both in Basal Condition and following Learning Predominantly Derives from the Maternal Allele.Ye X, Kohtz A, Pollonini G, Riccio A, Alberini CM2015PLoS ONE
Interaction between Methylation and CpG Single-Nucleotide Polymorphisms in the HTR2A Gene: Association Analysis with Suicide Attempt in Schizophrenia.Bani-Fatemi A, Howe AS, Matmari M, Koga A, Zai C, Strauss J, De Luca V2016Neuropsychobiology
Isolation of epiblast stem cells from preimplantation mouse embryos.Najm FJ, Chenoweth JG, Anderson PD, Nadeau JH, Redline RW, McKay RD, Tesar PJ2011Cell Stem Cell
KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803.Ogino S, Meyerhardt JA, Irahara N, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Schaefer P, Whittom R, Hantel A, Benson AB, Goldberg RM, Bertagnolli MM, Fuchs CS2009Clin. Cancer Res.
LINE-1 methylation is inherited in familial testicular cancer kindreds.Mirabello L, Savage SA, Korde L, Gadalla SM, Greene MH 2010BMC Med. Genet.
LINE-1 methylation levels in leukocyte DNA and risk of renal cell cancer.Liao LM, Brennan P, van Bemmel DM, Zaridze D, Matveev V, Janout V, Kollarova H, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Rothman N, Boffetta P, Chow WH, Moore LE2011PLoS ONE
Long human CHGA flanking chromosome 14 sequence required for optimal BAC transgenic "rescue" of disease phenotypes in the mouse Chga knockout. Vaingankar SM, Li Y, Corti A, Biswas N, Gayen J, O'Connor DT, Mahata SK2010Physiol. Genomics
Maintenance Therapy with Decitabine after Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome.Pusic I, Choi J, Fiala MA, Gao F, Holt M, Cashen AF, Vij R, Abboud CN, Stockerl-Goldstein KE, Jacoby MA, Uy GL, Westervelt P, DiPersio JF2015Biol. Blood Marrow Transplant.
MAOA promoter methylation and susceptibility to carotid atherosclerosis: role of familial factors in a monozygotic twin sample.Zhao J, Forsberg CW, Goldberg J, Smith NL, Vaccarino V2012BMC Med. Genet.
Maternal deprivation in rats is associated with corticotrophin-releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood.Chen J, Evans AN, Liu Y, Honda M, Saavedra JM, Aguilera G 2012J. Neuroendocrinol.
Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice.Dunn GA, Bale TL 2009Endocrinology
Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancer.King JA, Tan F, Mbeunkui F, Chambers Z, Cantrell S, Chen H, Alvarez D, Shevde LA, Ofori-Acquah SF2010Mol. Cancer
MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines.Dandrea M, Donadelli M, Costanzo C, Scarpa A, Palmieri M2009Nucleic Acids Res.
Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line.Hollevoet K, Mason-Osann E, Mller F, Pastan I2015PLoS ONE
Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells.Ge X, Ren Y, Bartulos O, Lee MY, Yue Z, Kim KY, Li W, Amos PJ, Bozkulak EC, Iyer A, Zheng W, Zhao H, Martin KA, Kotton DN, Tellides G, Park IH, Yue L, Qyang Y2012Circulation
Obesity related methylation changes in DNA of peripheral blood leukocytes.Wang X, Zhu H, Snieder H, Su S, Munn D, Harshfield G, Maria BL, Dong Y, Treiber F, Gutin B, Shi H 2010BMC Med
Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.Kim YC, Bhairavabhotla R, Yoon J, Golding A, Thornton AM, Tran DQ, Shevach EM2012Blood
Parental ages and levels of DNA methylation in the newborn are correlated.Adkins RM, Thomas F, Tylavsky FA, Krushkal J 2011BMC Med. Genet.
Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).Syed A, Garcia MA, Lyu SC, Bucayu R, Kohli A, Ishida S, Berglund JP, Tsai M, Maecker H, O'Riordan G, Galli SJ, Nadeau KC 2014J. Allergy Clin. Immunol.
Phase II study of extended-dose temozolomide in patients with melanoma.Rietschel P, Wolchok JD, Krown S, Gerst S, Jungbluth AA, Busam K, Smith K, Orlow I, Panageas K, Chapman PB2008J. Clin. Oncol.
PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.Nosho K, Kawasaki T, Ohnishi M, Suemoto Y, Kirkner GJ, Zepf D, Yan L, Longtine JA, Fuchs CS, Ogino S2008Neoplasia
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS2009J. Clin. Oncol.
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH2015Cell Rep
Prognostic methylation markers for overall survival in cytogenetically normal AML patients treated on SWOG trials.Xiaoyu Qu, Megan Othus, Jerry Davison, Yu Wu, Liying Yan, Soheil Meshinchi, Fabiana Ostronoff, Elihu Estey, Jerry Radich, Harry Erba, Frederick R. Appelbaum, and Min Fang2017Cancer
PTSD and DNA Methylation in Select Immune Function Gene Promoter Regions: A Repeated Measures Case-Control Study of U.S. Military Service Members. Rusiecki JA, Byrne C, Galdzicki Z, Srikantan V, Chen L, Poulin M, Yan L, Baccarelli A2013Front Psychiatry
Quantification of CpG island methylation in progressive breast lesions from normal to invasive carcinoma. Pasquali L, Bedeir A, Ringquist S, Styche A, Bhargava R, Trucco G2007Cancer Lett.
Quantitative allele-specific expression and DNA methylation analysis of H19, IGF2 and IGF2R in the human placenta across gestation reveals H19 imprinting plasticity.Buckberry S, Bianco-Miotto T, Hiendleder S, Roberts CT 2012PLoS ONE
Quantitative analysis of promoter methylation in exfoliated epithelial cells isolated from breast milk of healthy women.Wong CM, Anderton DL, Smith-Schneider S, Wing MA, Greven MC, Arcaro KF2010Epigenetics
Quantitative analysis of SNRPN(correction of SRNPN) gene methylation by pyrosequencing as a diagnostic test for Prader-Willi syndrome and Angelman syndrome.White HE, Durston VJ, Harvey JF, Cross NC2006Clin. Chem.
Quantitative high-resolution CpG island mapping with Pyrosequencing reveals disease-specific methylation patterns of the CDKN2B gene in myelodysplastic syndrome and myeloid leukemia.Brakensiek K, Wingen LU, Lnger F, Kreipe H, Lehmann U2007Clin. Chem.
Rapid identification of promoter hypermethylation in hepatocellular carcinoma by pyrosequencing of etiologically homogeneous sample pools.Dejeux E, Audard V, Cavard C, Gut IG, Terris B, Tost J2007J Mol Diagn
RASSF1 tumor suppressor gene in pancreatic ductal adenocarcinoma: correlation of expression, chromosomal status and epigenetic changes.Amato E, Barbi S, Fassan M, Luchini C, Vicentini C, Brunelli M, Malleo G, Scarpa A, Malpeli G2016BMC Cancer
Reactivation of epigenetically silenced HER4/ERBB4 results in apoptosis of breast tumor cells.Das PM, Thor AD, Edgerton SM, Barry SK, Chen DF, Jones FE 2010Oncogene
Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition. Lakshmikuttyamma A, Scott SA, DeCoteau JF, Geyer CR2010Oncogene
Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells.Liu T, Zhang X, So CK, Wang S, Wang P, Yan L, Myers R, Chen Z, Patterson AP, Yang CS, Chen X 2007Carcinogenesis
Relation of high neuroticism with increased methylation of the BDNF gene.Shirata T, Suzuki A, Matsumoto Y, Takahashi N, Noto K, Goto K, Otani K 2018Neuropsychiatr Dis Treat
Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences. Kang SW, Shih PA, Mathew RO, Mahata M, Biswas N, Rao F, Yan L, Bouchard J, Malhotra R, Tolwani A, Khandrika S, Mehta RL, O'Connor DT2011BMC Nephrol
Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M2015Cell Stem Cell
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY2010Nature
Role of DNMT3B in the regulation of early neural and neural crest specifiers. Martins-Taylor K, Schroeder DI, LaSalle JM, Lalande M, Xu RH2012Epigenetics
Selecting the most appropriate time points to profile in high-throughput studies.Kleyman M, Sefer E, Nicola T, Espinoza C, Chhabra D, Hagood JS, Kaminski N, Ambalavanan N, Bar-Joseph Z2017Elife
Sensitive quantitative analysis of murine LINE1 DNA methylation using high resolution melt analysis.Newman M, Blyth BJ, Hussey DJ, Jardine D, Sykes PJ, Ormsby RJ 2012Epigenetics
Sensitive sequencing method for KRAS mutation detection by Pyrosequencing.Ogino S, Kawasaki T, Brahmandam M, Yan L, Cantor M, Namgyal C, Mino-Kenudson M, Lauwers GY, Loda M, Fuchs CS2005J Mol Diagn
Sequential monitoring and stability of ex vivo-expanded autologous and nonautologous regulatory T cells following infusion in nonhuman primates.Zhang H, Guo H, Lu L, Zahorchak AF, Wiseman RW, Raimondi G, Cooper DK, Ezzelarab MB, Thomson AW2015Am. J. Transplant.
Sex-specific programming of offspring emotionality after stress early in pregnancy.Mueller BR, Bale TL 2008J. Neurosci.
Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain.Okhovat M, Berrio A, Wallace G, Ophir AG, Phelps SM2015Science
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1.Cho SH, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PD, Lo I, Minami S, Devidze N, Zhou Y, Coppola G, Gan L2015J. Neurosci.
The influence of obesity on folate status, DNA methylation and cancer-related gene expression in normal breast tissues from premenopausal women.Armina-Lyn M. Frederick, Chi Guo, Ann Meyer, Liying Yan, Sallie S. Schneider, and Zhenhua Liua2021Epigenetics
The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.Zizzari IG, Martufi P, Battisti F, Rahimi H, Caponnetto S, Bellati F, Nuti M, Rughetti A, Napoletano C2015PLoS ONE
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller DF, Pilrose J, Choy G, Azab M, Pawelczak KS, VanderVere-Carozza P, Wagner M, Lyons J, Matei D, Turchi JJ, Nephew KP2014Clin. Cancer Res.
The relationship between DNA methylation and telomere length in dyskeratosis congenita.Gadalla SM, Katki HA, Shebl FM, Giri N, Alter BP, Savage SA2012Aging Cell
Transcriptomic and epigenetic regulation of disuse atrophy and the return to activity in skeletal muscle.Fisher AG, Seaborne RA, Hughes TM, Gutteridge A, Stewart C, Coulson JM, Sharples AP, Jarvis JC2017FASEB J.
Two-hit exposure to polychlorinated biphenyls at gestational and juvenile life stages: 2. Sex-specific neuromolecular effects in the brain.Bell MR, Hart BG, Gore AC2016Mol. Cell. Endocrinol.
Two-round coamplification at lower denaturation temperature-PCR (COLD-PCR)-based sanger sequencing identifies a novel spectrum of low-level mutations in lung adenocarcinoma.Li J, Milbury CA, Li C, Makrigiorgos GM2009Hum. Mutat.
Variations in DNA methylation of interferon gamma and programmed death 1 in allograft rejection after kidney transplantation.Boer K, de Wit LE, Peters FS, Hesselink DA, Hofland LJ, Betjes MG, Looman CW, Baan CC2016Clin Epigenetics
Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. Kure S, Nosho K, Baba Y, Irahara N, Shima K, Ng K, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S2009Cancer Epidemiol. Biomarkers Prev.
NR3C1 methylation as a moderator of the effects of maternal support and stress on insecure attachment developmentGuy Bosmans, Jami Young, Benjamin L. Hankin2017Dev Psychol.
High Expression of IKZF2 in Malignant T Cells Promotes Disease Progression in Cutaneous T Cell LymphomaBufang XU, Fengjie LIU, Yumei GAO, Jingru SUN, Yingyi LI, Yuchieh LIN, Xiangjun LIU, Yujie WEN, Shengguo YI, Jingyang DANG, Ping TU, and Yang WANG2021Acta Derm Venereol.
DNA methylation patterns associated with konzo in Sub-Saharan AfricaDNA methylation, Epigenetics, EPIC array, targeted next-generation bisulfite sequencing, EPIC array validationKristen Kocher, Surajit Bhattacharya, Matthew S Bramble, Daniel Okitundu-Luwa, Dieudonne Mumba Ngoyi, Desire Tshala-Katumbay, Eric Vilain2022Clin Epigenetics

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