Assess the average amount of DNA methylation globally within a sample by Pyrosequencing.
Repetitive elements (such as the LINE/Alu elements in humans), constitute close to 45% of the mammalian genome. It is thus a routine method to measure global DNA methylation levels by analyzing these repetitive fragments.
EpigenDx analyzes methylation by direct Pyrosequencing after bisulfite conversion of DNA. All of our assays are pre-validated to ensure there is no preferential amplification for either methylated or unmethylated DNA, allowing us to provide you with the highest quality data and results.