Have a Question? 800.941.6884 · info@epigendx.com

PIK3CA Assay

PIK3CA Gene Methylation

PIK3CA Methylation Analysis

Composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit, Phosphatidylinositol 3-kinase has been found to be oncogenic and has been implicated in cervical cancers. PIK3CA is the most commonly mutated gene in HR+/HER2- advanced breast cancer1.  The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2.

Get In Touch
PIK3CA Methylation Analysis

Did You Know?

40% of patients with HR+/HER2-advanced breast cancer have PIK3CA mutation1

PIK3CA Mutation

PIK3CA is the most commonly mutated gene in breast cancer, and it has been linked to a variety of cancers. The 542/545 area of the helical domain and the 1047 region of the kinase domain have long been recognized as hotspots for activating mutations in PIK3CA, which is a key element of the PI3K pathway. PIK3CA and its interactions with the AKT and mTOR pathways have sparked a lot of study and development, and PI3K inhibition has had some limited success in clinical trials recently. While monotherapies appear to have limited efficacy, there has recently been renewed interest in using PI3K inhibition as part of a combination therapy approach.

Request A Quote

How It Works

EpigenDx idea icon

Tell Us About Your Project

EpigenDx mail icon

Send Us Your Sample

EpigenDx laboratory icon

Receive Your Data

GLP and GCP Compliant Laboratory Services & Custom Assay Designs.

References:

1. The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature.2012;490(7418):61-70.

Limited Time Offer: 30% Off Our Custom NGS Panel Design Service

X