In this publication, researchers investigate whether MYC DNA methylation at 8q24 (six CpG sites from exon 3 to the 3′ UTR) in prostate tumor was associated with tumor aggressiveness (based on Gleason score, GS), and incorporate RNA expression data to investigate the function. In preparation for the DNA methylation assays, the University of Maryland FFPE samples were sent to EpigenDx, Inc. (Hopkinton, MA, USA), where direct bisulfite treatment was performed on digested FFPE tissue.
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